Treatment with low-dose diazoxide in two growth-retarded prepubertal girls with glycogen storage disease type Ia resulted in catch-up growth.
Nuoffer JM, Mullis PE, Wiesmann UN.
Division of Endocrinology and Metabolism, University Children's Hospital, Bern, Switzerland.
Two originally prepubertal girls suffering from glycogen storage disease type Ia and short stature were treated with low-dose diazoxide (3-4.8 mg/kg per day) for 7 and 4 years, respectively. Both showed an impressive catch-up growth following this treatment. This appeared to be due to prolongation of normoglycaemia after meals and reduction of fasting lactic acidosis by diazoxide.
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PMID: 9427147 [PubMed - indexed for MEDLINE]