Bilateral testicular enlargement and seminoma in a patient with acromegaly.
Abraham D, Couldwell WT.
Division of Endocrinology & Metabolism, Department of Internal Medicine, University of Utah, Salt Lake City 84132, USA.
Growth hormone (GH) excess has been associated with soft tissue changes and an increase in the incidence of colonic polyps and gastrointestinal cancer. We describe a patient with endogenous GH excess caused by a pituitary tumour, resulting in acromegaly. The patient had bilateral testicular enlargement, with tumour of the right testicle. Pituitary MRI revealed a macroadenoma. After resection of the pituitary tumour, GH levels fell below 0.5 ng/ml, with acromegaly resolution. Testicular resection revealed seminoma. Following acromegaly resolution, the enlarged remaining testicle decreased in size. The implications of the testicular enlargement and seminoma in the presence of a GH-secreting tumour are discussed.
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PMID: 15799199 [PubMed - indexed for MEDLINE]