Open Access Highly Accessed Open Badges Case report

Systemic lupus erythematosus associated with sickle-cell disease: a case report and literature review

Mouna Maamar*, Zoubida Tazi-Mezalek, Hicham Harmouche, Wafaa Mounfaloti, Mohammed Adnaoui and Mohammed Aouni

Author Affiliations

Department of Internal Medicine, Ibn Sina Hospital, Rabat, Morocco

For all author emails, please log on.

Journal of Medical Case Reports 2012, 6:366  doi:10.1186/1752-1947-6-366

Published: 26 October 2012



The occurrence of systemic lupus erythematosus has been only rarely reported in patients with sickle-cell disease.

Case presentation

We describe the case of a 23-year-old North-African woman with sickle-cell disease and systemic lupus erythematosus, and discuss the pointers to the diagnosis of this combination of conditions and also present a review of literature. The diagnosis of systemic lupus erythematosus was delayed because our patient’s symptoms were initially attributed to sickle-cell disease.


Physicians should be alerted to the possible association of sickle-cell disease and systemic lupus erythematosus so as not to delay correct diagnosis and initiation of appropriate treatment.

Sickle-cell disease; systemic lupus erythematosus