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Daptomycin efficacy in the central nervous system of a patient with disseminated methicillin-resistant Staphylococcus aureus infection: a case report

Fabrizio Taglietti1*, Floriana Campanile2, Alessandro Capone1, Antonino Di Caro3, Elisabetta Grilli1, Giulia Stazi4, Taschia Bertuccio2, Nicola Petrosillo1 and Stefania Stefani2

Author Affiliations

1 Second Infectious Diseases Division, National Institute for Infectious Diseases “LazzaroSpallanzani”, Via Portuense, 292-00149, Rome, Italy

2 Department of Microbiology, University of Catania, Catania, Italy

3 Department of Microbiology and Virology, National Institute for Infectious Diseases “LazzaroSpallanzani”, Rome, Italy

4 Intensive Care Unit, National Institute for Infectious Diseases “LazzaroSpallanzani”, Rome, Italy

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Journal of Medical Case Reports 2012, 6:264  doi:10.1186/1752-1947-6-264

Published: 31 August 2012



Staphylococcus aureus has emerged as a major nosocomial pathogen in the last decades and also represents the second most common pathogen isolated from patients in outpatient settings. Although methicillin-resistant S.aureus infections were traditionally limited to hospitals, community-associated cases of methicillin-resistant S.aureus infections have been reported. In our case, we observed an unexpected event during treatment.

Case presentation

A 60-year-old Caucasian man developed fever and multiple muscle and brain abscesses caused by Panton-Valentine leukocidin-negative community-associated methicillin-resistant S. aureus.


Although our patient was given antimicrobials active against the isolated methicillin-resistant S. aureus strain, it was only after the introduction of daptomycin that his skin, soft tissue and muscle lesions and also brain manifestations improved.