Anemia secondary to valproic acid therapy in a 13-year-old boy: a case report
1 Department of Pediatrics, Hematology, Oncology, and Endocrinology, Medical University of Gdansk, Gdansk, Poland
2 Department of Developmental Neurology, Medical University of Gdansk, Gdansk, Poland
Journal of Medical Case Reports 2012, 6:239 doi:10.1186/1752-1947-6-239Published: 10 August 2012
Valproic acid is a commonly used anti-epileptic drug. Hematological toxicities are among the occasionally observed adverse effects of this medication.
We present the case of a 13-year-old Caucasian boy who demonstrated mild anemia 12 months after the introduction of valproic acid therapy. A bone marrow biopsy revealed maturation arrest of proerythroblasts.
Prompt diagnosis and valproic acid discontinuation resulted in the patient’s recovery.