A 43-year-old woman on triptorelin presenting with pseudotumor cerebri: a case report
1 Department of Ophthalmology, Queen’s Medical Centre, Nottingham, NG7 2UH, UK
2 Birmingham and Midland Eye Centre, Dudley Road, West Midlands, B18 7QH, UK
3 Sussex Eye Hospital, Brighton, East Sussex, BN2 5BF, UK
4 Department of Ophthalmology, Leicester Royal Infirmary, Leicester, LE1 5WW, UK
Journal of Medical Case Reports 2012, 6:122 doi:10.1186/1752-1947-6-122Published: 3 May 2012
To the best of our knowledge, this is the first time triptorelin has been reported to cause benign intracranial hypertension.
A 43-year-old Caucasian woman who suffered from chronic menorrhagia was started on triptorelin, a gonadotrophin-releasing hormone analogue. Three days later, she developed gradually worsening headaches accompanied by bilateral visual disturbance. Examination revealed bilateral papilledema and enlarged blind spots on her visual fields. A diagnosis of benign intracranial hypertension was made and confirmed on magnetic resonance imaging.
We recommend that patients at high risk (women who are overweight and of reproductive age) who are using any gonadotrophin-releasing hormone analogue (for example, triptorelin) should be periodically monitored for the possible development of benign intracranial hypertension.