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Open Access Case report

Adult granulosa cell tumor associated with endometrial carcinoma: a case report

Cornelius O Ukah1, Okechukwu C Ikpeze2, George U Eleje2 and Ahizechukwu C Eke3*

Author Affiliations

1 Department of Histopathology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria

2 Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria

3 Health Policy and Management concentration, Masters in Public Health Program, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA

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Journal of Medical Case Reports 2011, 5:340  doi:10.1186/1752-1947-5-340

Published: 2 August 2011

Abstract

Introduction

If strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered, the best estimate of the incidence of associated endometrial carcinomas is under 5%. In patients with granulosa cell tumors, estrogen-dependent endometrial cancers are rarely found, and most of these endometrial cancers are well-differentiated endometrioid adenocarcinomas that carry a good prognosis when detected early.

Case presentation

We report the case of a 65-year-old post-menopausal Nigerian woman of the Igbo tribe with an adult granulosa cell tumor that was initially treated as endometrial carcinoma. She underwent a total abdominal hysterectomy and a bilateral salpingo-oophorectomy after histopathologic confirmation of a well-differentiated granulosa cell tumor of the ovary and a nuclear grade 1 adenocarcinoma of the endometrium (International Federation of Obstetricians and Gynecologists stage 1B). She had a good post-operative recovery and was discharged 10 days after treatment.

Conclusion

The association between adult granulosa cell tumors of the ovary and endometrial carcinomas is rare. A high index of suspicion as well as good imaging and histopathologic analyses are important in making this diagnosis.