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Open Access Highly Accessed Case report

Fatal invasive cervical cancer secondary to untreated cervical dysplasia: a case report

Stephan Braun1, Daniel Reimer1, Isolde Strobl1, Ulrike Wieland2, Petra Wiesbauer1, Elisabeth Müller-Holzner1, Siegfried Fessler1, Arthur Scherer3, Christian Marth1 and Alain G Zeimet1*

Author Affiliations

1 Department of Obstetrics and Gynecology, Innsbruck Medical University, Anichstrasse 35, AT-6020 Innsbruck, Austria

2 Institute of Virology, University of Cologne, Fürst-Prückler-Strasse 65, D-50935 Cologne, Germany

3 Department of Obstetrics and Gynecology, Medical Services Hospital, Bressanone, Italy

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Journal of Medical Case Reports 2011, 5:316  doi:10.1186/1752-1947-5-316

Published: 18 July 2011



Well-documented cases of untreated cervical intra-epithelial dysplasia resulting in fatal progression of invasive cervical cancer are scarce because of a long pre-invasive state, the availability of cervical cytology screening programs, and the efficacy of the treatment of both pre-invasive and early-stage invasive lesions.

Case presentation

We present a well-documented case of a 29-year-old Caucasian woman who was found, through routine conventional cervical cytology screening, to have pathologic Papanicolaou (Pap) grade III D lesions (squamous cell abnormalities). She subsequently died as a result of human papillomavirus type 18-associated cervical cancer after she refused all recommended curative therapeutic procedures over a period of 13 years.


This case clearly demonstrates a caveat against the promotion and use of complementary alternative medicine as pseudo-immunologic approaches outside evidence-based medicine paths. It also demonstrates the impact of the individualized demands in diagnosis, treatment and palliative care of patients with advanced cancer express their will to refuse evidence-based treatment recommendations.