Fatal invasive cervical cancer secondary to untreated cervical dysplasia: a case report
1 Department of Obstetrics and Gynecology, Innsbruck Medical University, Anichstrasse 35, AT-6020 Innsbruck, Austria
2 Institute of Virology, University of Cologne, Fürst-Prückler-Strasse 65, D-50935 Cologne, Germany
3 Department of Obstetrics and Gynecology, Medical Services Hospital, Bressanone, Italy
Journal of Medical Case Reports 2011, 5:316 doi:10.1186/1752-1947-5-316Published: 18 July 2011
Well-documented cases of untreated cervical intra-epithelial dysplasia resulting in fatal progression of invasive cervical cancer are scarce because of a long pre-invasive state, the availability of cervical cytology screening programs, and the efficacy of the treatment of both pre-invasive and early-stage invasive lesions.
We present a well-documented case of a 29-year-old Caucasian woman who was found, through routine conventional cervical cytology screening, to have pathologic Papanicolaou (Pap) grade III D lesions (squamous cell abnormalities). She subsequently died as a result of human papillomavirus type 18-associated cervical cancer after she refused all recommended curative therapeutic procedures over a period of 13 years.
This case clearly demonstrates a caveat against the promotion and use of complementary alternative medicine as pseudo-immunologic approaches outside evidence-based medicine paths. It also demonstrates the impact of the individualized demands in diagnosis, treatment and palliative care of patients with advanced cancer express their will to refuse evidence-based treatment recommendations.