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Open Access Highly Accessed Case report

Gastrointestinal relapse of multiple myeloma and sustained response to lenalidomide: a case report

Patrick R Benusiglio1*, Thomas A McKee2, Xavier Montet3, Jean-Marc Dumonceau4, Laurence Favet1, Anne-Claude George1 and Pierre-Yves Dietrich1

Author Affiliations

1 Centre for Oncology, Geneva University Hospital, 4 rue Gabrielle Perret-Gentil, 1211 Geneva 14, Switzerland

2 Department of Pathology, Geneva University Hospital, 4 rue Gabrielle Perret-Gentil, 1211 Geneva 14, Switzerland

3 Department of Radiology, Geneva University Hospital, 4 rue Gabrielle Perret-Gentil, 1211 Geneva 14, Switzerland

4 Department of Gastroenterology, Geneva University Hospital, 4 rue Gabrielle Perret-Gentil, 1211 Geneva 14, Switzerland

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Journal of Medical Case Reports 2011, 5:110  doi:10.1186/1752-1947-5-110

Published: 19 March 2011

Abstract

Introduction

Gastrointestinal relapse in patients with multiple myeloma is very rare and, when reported, always associated with a poor prognosis.

Case presentation

We describe the case of a 71-year-old Caucasian man who presented with life-threatening hematemesis and melena due to a digestive relapse of his multiple myeloma. Despite the active hemorrhage, we initiated a third-line treatment with lenalidomide. The response was spectacular and long-lasting.

Conclusions

Clinicians must consider digestive tract involvement in myeloma patients presenting with a gastrointestinal hemorrhage. Furthermore, myeloma patients do benefit from novel oral drugs, even when they are critically ill.