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Eosinophilic infiltrate in a patient with severe Legionella pneumonia as a levofloxacin-related complication: a case report

Nicola Facciolongo1*, Francesco Menzella1, Claudia Castagnetti1, Alberto Cavazza2, Roberto Piro1, Cristiano Carbonelli1 and Luigi Zucchi1

Author Affiliations

1 Department of Pneumology, S. Maria Nuova Hospital, 42123 Reggio Emilia, Italy

2 Department of Pathology, S. Maria Nuova Hospital, 42123 Reggio Emilia, Italy

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Journal of Medical Case Reports 2010, 4:360  doi:10.1186/1752-1947-4-360

Published: 11 November 2010



Legionella pneumonia can appear with different levels of severity and it can often present with complications such as acute respiratory distress syndrome.

Case presentation

We report the case of a 44-year-old Caucasian man with Legionella pneumonia with successive development of severe acute respiratory distress syndrome. During his stay in intensive care the clinical and radiological situation of the previously observed acute respiratory distress syndrome unexpectedly worsened due to acute pulmonary eosinophilic infiltrate of iatrogenic origin.


Levofloxacin treatment caused the occurrence of acute eosinophilic infiltrate. Diagnosis was possible following bronchoscopic examination using bronchoaspirate and transbronchial biopsy.