Email updates

Keep up to date with the latest news and content from Journal of Medical Case Reports and BioMed Central.

Open Access Case report

Unsuspected Pneumocystis pneumonia in an HIV-seronegative patient with untreated lung cancer: circa case report

Cai Chuang*, Xie Zhanhong, Gu Yinyin, Zeng Qingsi, Zhong Shuqing and Zhong Nanshan

Author Affiliations

Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510012, China.

For all author emails, please log on.

Journal of Medical Case Reports 2007, 1:115  doi:10.1186/1752-1947-1-115

Published: 28 October 2007

Abstract

Background

Patients with solid malignant tumours are at increased risk of Pneumocystis jiroveci infection from immunosuppression as a result of chemotherapy and/or radiotherapy, but active Pneumocystis pneumonia (PCP) in untreated lung cancer is uncommon.

Case presentation

A 43-year-old woman presented with prolonged fever, progressive dyspnoea, diffuse alveolar and interstitial infiltrates. Malignant cells were found on sputum cytology, confirming the diagnosis of lung cancer. She had been treated with corticosteroids and antibiotics but did not receive chemotherapy or radiotherapy. Pneumocystis jiroveci was later found in the sputum but she proved to be HIV negative.

Conclusion

Unsuspected PCP can occur in chemotherapy and radiotherapy-naïve, HIV-seronegative patients with lung cancer. The complex clinicoradiological manifestations of PCP with underlying lung cancer can lead to delay in diagnosis and may worsen the prognosis.